Medicine

Advancing ASO treatments coming from development to application

.Completing rate of interests.R.S., M.S., H.G. and A.A.R. are actually organizers of the 1M1M project. H.G. and A.A.R. are panel of supervisors participants and also R.S., M.S. as well as A.A.R. are participants of the clinical advisory committee of N1C. A.A.R. discloses work by LUMC, which possesses licenses on exon-skipping innovation, some of which has actually been actually licensed to BioMarin and also consequently sublicensed to Sarepta. As co-inventor of some of these licenses, A.A.R. was qualified to a portion of royalties. A.A.R. further makes known working as consultant for PTC Therapeutics, Sarepta Therapies, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. In the past 5 years, A.A.R. additionally performed ad hoc consulting for Alpha Anomeric. A.A.R. likewise states membership of the clinical boards of advisers of Eisai, Hybridize Therapeutics, Silence Rehabs, Sarepta Rehabs, Sapreme as well as Mitorx. Over the last 5 years, A.A.R. was actually also a scientific advisory board participant for ProQR. Reimbursement for A.A.R. u00e2 s consulting and also advising tasks is paid to LUMC. Before 5 years, LUMC additionally received audio speaker gratuity from PTC Therapeutics, Alnylam Netherlands, Italfarmaco and also Pfizer as well as financing for agreement study coming from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Job financing is gotten coming from Sarepta Rehabs and Entrada by means of unregulated gives. H.G. possesses nothing to make known relative to the topics dealt with within this composition. Before 5 years, he has likewise received working as a consultant honoraria from UCB. M.S. obtained working as a consultant honoraria coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa in the past 5 years, all unassociated to the present manuscript. R.S. has absolutely nothing to disclose in connection with the subject matters dealt with within this composition. She has actually acquired audio speaker and/or consultancy gratuity or sponsoring payments coming from Abbvie, Bial, STADA and also Everpharma previously 5 years.

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